Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC005
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-18 04:10
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Carboma 100mg 4x1;caps Madopar HBS 250mg 1x1;tbl Oprimea 0,52mg 1x1; tbl Rivotril 2mg 1/4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 15, 'TP': 19, 'FP': 15}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 7.86545
timePerCircleCoV 0.205424
timePerCircleSlope 0.00120203
meanError 1.57127
tremorFreq 7.42188
tremorRelPower 30.8654
tremorGyroAmpMean 0.0348323
tremorGyroAmpSlope 0.00364034
tremorGyroAmpCoV 0.306872
tremorCoordAmpMean 0.0824776
tremorCoordAmpSlope -0.00298829
tremorCoordAmpCoV 0.368566
tremorAccAmpMean 0.084081
tremorAccAmpSlope -0.00164537
tremorAccAmpCoV 0.406876
tremorPcRelVar 0.690688
tremorPcX -0.0172423
tremorPcY 0.999851

Circle Segment 1

Duration 4.84 s, Accuracy Estimate 3.125 (lower is better)

Circle Segment 2

Duration 7.52 s, Accuracy Estimate 2.311 (lower is better)

Circle Segment 3

Duration 9.16 s, Accuracy Estimate 1.292 (lower is better)

Circle Segment 4

Duration 8.28 s, Accuracy Estimate 1.361 (lower is better)

Circle Segment 5

Duration 8.52 s, Accuracy Estimate 1.194 (lower is better)

Circle Segment 6

Duration 8.8 s, Accuracy Estimate 1.381 (lower is better)

Circle Segment 7

Duration 10.92 s, Accuracy Estimate 1.366 (lower is better)

Circle Segment 8

Duration 7.56 s, Accuracy Estimate 1.035 (lower is better)

Circle Segment 9

Duration 7.72 s, Accuracy Estimate 1.685 (lower is better)

Circle Segment 10

Duration 7.32 s, Accuracy Estimate 1.386 (lower is better)

Circle Segment 11

Duration 5.88 s, Accuracy Estimate 1.147 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 28.144
timePerSpiralCoV 0.0965975
timePerSpiralSlope -0.0152463
meanError 1.59991
tremorFreq 6.05469
tremorRelPower 25.8988
tremorGyroAmpMean 0.0570593
tremorGyroAmpSlope 0.00135658
tremorGyroAmpCoV 0.41079
tremorCoordAmpMean 0.0725379
tremorCoordAmpSlope 0.000658772
tremorCoordAmpCoV 0.420176
tremorAccAmpMean 0.0925769
tremorAccAmpSlope 0.000557569
tremorAccAmpCoV 0.373871
tremorPcRelVar 0.665097
tremorPcX 0.554638
tremorPcY -0.832092

Spiral Segment 1

Duration 26.76 s, Accuracy Estimate 1.677 (lower is better)

Spiral Segment 2

Duration 29.04 s, Accuracy Estimate 1.622 (lower is better)

Spiral Segment 3

Duration 33.04 s, Accuracy Estimate 1.68 (lower is better)

Spiral Segment 4

Duration 31.72 s, Accuracy Estimate 1.535 (lower is better)

Spiral Segment 5

Duration 29.36 s, Accuracy Estimate 1.457 (lower is better)

Spiral Segment 6

Duration 24.36 s, Accuracy Estimate 1.666 (lower is better)

Spiral Segment 7

Duration 26.8 s, Accuracy Estimate 1.757 (lower is better)

Spiral Segment 8

Duration 27.32 s, Accuracy Estimate 1.342 (lower is better)

Spiral Segment 9

Duration 27.84 s, Accuracy Estimate 1.932 (lower is better)

Spiral Segment 10

Duration 25.2 s, Accuracy Estimate 1.332 (lower is better)

Elel

eDurationMean 0.354727
eDurationStd 0.0567049
eDurationStdnorm 0.159855
eDurationMedian 0.360022
eDurationQuartdelta 0.0450027
eDurationQuartdeltanorm 0.125
eDurationKurt 3.42509
eDurationTrenddiff 0.0050003
eDurationTrendratio 1.01389
eWidthMean 5.98537
eWidthStd 1.65785
eWidthStdnorm 0.276984
eWidthMedian 5.88683
eWidthQuartdelta 2.11411
eWidthQuartdeltanorm 0.359126
eWidthKurt 3.03116
eWidthTrenddiff 0.458024
eWidthTrendratio 1.08141
eHeightMean 16.4544
eHeightStd 5.6299
eHeightStdnorm 0.342151
eHeightMedian 15.9222
eHeightQuartdelta 7.3189
eHeightQuartdeltanorm 0.459667
eHeightKurt 2.68614
eHeightTrenddiff 3.00629
eHeightTrendratio 1.20991
eAspectMean 0.401187
eAspectStd 0.149898
eAspectStdnorm 0.373638
eAspectMedian 0.414075
eAspectQuartdelta 0.177219
eAspectQuartdeltanorm 0.427987
eAspectKurt 3.46445
eAspectTrenddiff -0.132927
eAspectTrendratio 0.721664
eSlantMean -0.522048
eSlantStd 0.341068
eSlantStdnorm -0.653327
eSlantMedian -0.485223
eSlantQuartdelta 0.50622
eSlantQuartdeltanorm -1.04327
eSlantKurt 2.56902
eSlantTrenddiff 0.0720162
eRtopMean 0.478702
eRtopStd 0.273986
eRtopStdnorm 0.572351
eRtopMedian 0.409502
eRtopQuartdelta 0.387736
eRtopQuartdeltanorm 0.946849
eRtopKurt 2.13748
eRtopTrenddiff -0.0657871
eRbotMean 1.80664
eRbotStd 0.617729
eRbotStdnorm 0.341921
eRbotMedian 1.81739
eRbotQuartdelta 0.996126
eRbotQuartdeltanorm 0.548108
eRbotKurt 2.55876
eRbotTrenddiff 0.385312
eRrightMean 0.695851
eRrightStd 0.183852
eRrightStdnorm 0.264211
eRrightMedian 0.69289
eRrightQuartdelta 0.279252
eRrightQuartdeltanorm 0.403024
eRrightKurt 2.48799
eRrightTrenddiff -0.0292955
eRleftMean 0.68766
eRleftStd 0.140235
eRleftStdnorm 0.20393
eRleftMedian 0.708288
eRleftQuartdelta 0.235562
eRleftQuartdeltanorm 0.332579
eRleftKurt 2.24657
eRleftTrenddiff -0.00959265
lDurationMean 0.454559
lDurationStd 0.0648407
lDurationStdnorm 0.142645
lDurationMedian 0.457528
lDurationQuartdelta 0.0800048
lDurationQuartdeltanorm 0.174863
lDurationKurt 2.74735
lDurationTrenddiff -0.0525032
lDurationTrendratio 0.891753
lWidthMean 5.87893
lWidthStd 1.97728
lWidthStdnorm 0.336333
lWidthMedian 5.87243
lWidthQuartdelta 1.81366
lWidthQuartdeltanorm 0.308843
lWidthKurt 11.6726
lWidthTrenddiff 0.160507
lWidthTrendratio 1.02777
lHeightMean 40.1659
lHeightStd 4.21706
lHeightStdnorm 0.104991
lHeightMedian 39.8707
lHeightQuartdelta 6.14447
lHeightQuartdeltanorm 0.15411
lHeightKurt 2.34586
lHeightTrenddiff 4.61392
lHeightTrendratio 1.11911
lAspectMean 0.148179
lAspectStd 0.0525145
lAspectStdnorm 0.3544
lAspectMedian 0.144982
lAspectQuartdelta 0.0504536
lAspectQuartdeltanorm 0.347998
lAspectKurt 9.5895
lAspectTrenddiff -0.0101367
lAspectTrendratio 0.931195
lSlantMean -0.275351
lSlantStd 0.127412
lSlantStdnorm -0.462727
lSlantMedian -0.271024
lSlantQuartdelta 0.163474
lSlantQuartdeltanorm -0.603172
lSlantKurt 4.96477
lSlantTrenddiff 0.00345004
lRtopMean 0.42692
lRtopStd 0.212496
lRtopStdnorm 0.497744
lRtopMedian 0.476817
lRtopQuartdelta 0.244255
lRtopQuartdeltanorm 0.512262
lRtopKurt 3.18767
lRtopTrenddiff -0.0920837
lRbotMean 2.50763
lRbotStd 0.936171
lRbotStdnorm 0.37333
lRbotMedian 2.36998
lRbotQuartdelta 1.28743
lRbotQuartdeltanorm 0.543225
lRbotKurt 2.90412
lRbotTrenddiff 0.0495615
lRrightMean 0.670963
lRrightStd 0.127093
lRrightStdnorm 0.189418
lRrightMedian 0.663918
lRrightQuartdelta 0.204705
lRrightQuartdeltanorm 0.308329
lRrightKurt 2.51247
lRrightTrenddiff 0.0255323
lRleftMean 0.717592
lRleftStd 0.146208
lRleftStdnorm 0.203748
lRleftMedian 0.719217
lRleftQuartdelta 0.180725
lRleftQuartdeltanorm 0.25128
lRleftKurt 3.66488
lRleftTrenddiff 0.135146

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.911226
sumTouchScores 30.0705
meanMovementTime 0.572344
numTouches 33
undershootPercentage 0
overshootPercentage 15.1515

FITTS Long Modified

meanTouchScore 0.826524
sumTouchScores 17.357
meanMovementTime 0.70175
numTouches 21
undershootPercentage 0
overshootPercentage 19.0476

ZigZag

numZigzags 5
timePerZigzagMean 14.464
timePerZigzagCoV 0.28082
timePerZigzagSlope 0.174502
meanError 2.81923
tremorFreq 6.25
tremorRelPower 23.5645
tremorGyroAmpMean 0.055045
tremorGyroAmpSlope -0.0168258
tremorGyroAmpCoV 0.365301
tremorCoordAmpMean 0.123318
tremorCoordAmpSlope -0.0215196
tremorCoordAmpCoV 0.386419
tremorAccAmpMean 0.123089
tremorAccAmpSlope -0.0083752
tremorAccAmpCoV 0.219425
tremorPcRelVar 0.727322
tremorPcX 0.766201
tremorPcY 0.642601

ZigZag Segment 1

Duration 9.04 s, Accuracy Estimate 3.748 (lower is better)

ZigZag Segment 2

Duration 12.6 s, Accuracy Estimate 2.95 (lower is better)

ZigZag Segment 3

Duration 14.8 s, Accuracy Estimate 2.661 (lower is better)

ZigZag Segment 4

Duration 15.84 s, Accuracy Estimate 2.502 (lower is better)

ZigZag Segment 5

Duration 20.04 s, Accuracy Estimate 2.236 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.472
timePerZigzagCoV 0.17643
timePerZigzagSlope -0.0224503
zigzagHeightMean 65.6989
zigzagHeightCoV 0.0462944
zigzagHeightSlope 0.0151856
meanError 0.0617522
tremorFreq 6.83594
tremorRelPower 22.2069
tremorGyroAmpMean 0.0513577
tremorGyroAmpSlope -0.00475665
tremorGyroAmpCoV 0.40448
tremorCoordAmpMean 0.120597
tremorCoordAmpSlope -0.00666981
tremorCoordAmpCoV 0.303461
tremorAccAmpMean 0.0714148
tremorAccAmpSlope -0.0104333
tremorAccAmpCoV 0.333605
tremorPcRelVar 0.643433
tremorPcX 0.467722
tremorPcY 0.883876

ZigZag Offset Segment 1

Duration 12.0 s, Accuracy Estimate 0.064 (lower is better)

ZigZag Offset Segment 2

Duration 11.6 s, Accuracy Estimate 0.09 (lower is better)

ZigZag Offset Segment 3

Duration 15.84 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 4

Duration 13.04 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 5

Duration 9.88 s, Accuracy Estimate 0.074 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.65}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7493202728967612}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8327291866904247}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}